Predictors to Assess Non‐Sentinel Lymph Node Status in Breast Cancer Patients with Sentinel Lymph Node Metastasis
Identifieur interne : 006D65 ( Main/Exploration ); précédent : 006D64; suivant : 006D66Predictors to Assess Non‐Sentinel Lymph Node Status in Breast Cancer Patients with Sentinel Lymph Node Metastasis
Auteurs : Hiromitsu Jinno ; Michio Sakata ; Sota Asaga ; Masahiro Wada ; Toshiyuki Shimada ; Yuko Kitagawa ; Takayuki Suzuki ; Tadaki Nakahara ; Naoto Kitamura ; Atsushi Kubo ; Makio Mukai [Japon] ; Tadashi Ikeda [Japon] ; Masaki Kitajima [Japon]Source :
- The Breast Journal [ 1075-122X ] ; 2008-11.
Abstract
Abstract: The next step of sentinel lymph node biopsy (SLNB) in breast cancer is to determine which patients need axillary lymph node dissection (ALND) following a positive SLNB. A prospective database of 239 patients who underwent SLNB followed by complete ALND at Keio University Hospital from January 2001 to June 2005 was reviewed. A total of 131 patients with one or more positive sentinel lymph nodes (SLNs) were further analyzed. A univariate analysis showed a significant correlation between non‐SLN involvement and lymphatic invasion, vascular invasion, number of tumor‐involved SLNs, radioactivity of SLNs, and size of SLN metastasis (p = 0.0002, p = 0.004, p = 0.006, p = 0.04, p = 0.03, respectively). By multivariate analysis, lymphatic invasion and the number of tumor‐involved SLNs remained significant predictors of non‐SLN involvement. In breast cancer patients with a positive SLN, lymphatic invasion and the number of tumor‐involved SLNs were both independent predictors of non‐SLN involvement.
Url:
DOI: 10.1111/j.1524-4741.2008.00646.x
Affiliations:
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Kantō</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">The Breast Journal</title><title level="j" type="alt">BREAST JOURNAL</title><idno type="ISSN">1075-122X</idno><idno type="eISSN">1524-4741</idno><imprint><biblScope unit="vol">14</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="551">551</biblScope><biblScope unit="page" to="555">555</biblScope><biblScope unit="page-count">7</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2008-11">2008-11</date></imprint><idno type="ISSN">1075-122X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1075-122X</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Abstract: The next step of sentinel lymph node biopsy (SLNB) in breast cancer is to determine which patients need axillary lymph node dissection (ALND) following a positive SLNB. A prospective database of 239 patients who underwent SLNB followed by complete ALND at Keio University Hospital from January 2001 to June 2005 was reviewed. A total of 131 patients with one or more positive sentinel lymph nodes (SLNs) were further analyzed. A univariate analysis showed a significant correlation between non‐SLN involvement and lymphatic invasion, vascular invasion, number of tumor‐involved SLNs, radioactivity of SLNs, and size of SLN metastasis (p = 0.0002, p = 0.004, p = 0.006, p = 0.04, p = 0.03, respectively). By multivariate analysis, lymphatic invasion and the number of tumor‐involved SLNs remained significant predictors of non‐SLN involvement. In breast cancer patients with a positive SLN, lymphatic invasion and the number of tumor‐involved SLNs were both independent predictors of non‐SLN involvement.</div></front></TEI><affiliations><list><country><li>Japon</li></country><region><li>Région de Kantō</li></region><settlement><li>Tokyo</li></settlement></list><tree><noCountry><name sortKey="Asaga, Sota" sort="Asaga, Sota" uniqKey="Asaga S" first="Sota" last="Asaga">Sota Asaga</name><name sortKey="Jinno, Hiromitsu" sort="Jinno, Hiromitsu" uniqKey="Jinno H" first="Hiromitsu" last="Jinno">Hiromitsu Jinno</name><name sortKey="Kitagawa, Yuko" sort="Kitagawa, Yuko" uniqKey="Kitagawa Y" first="Yuko" last="Kitagawa">Yuko Kitagawa</name><name sortKey="Kitamura, Naoto" sort="Kitamura, Naoto" uniqKey="Kitamura N" first="Naoto" last="Kitamura">Naoto Kitamura</name><name sortKey="Kubo, Atsushi" sort="Kubo, Atsushi" uniqKey="Kubo A" first="Atsushi" last="Kubo">Atsushi Kubo</name><name sortKey="Nakahara, Tadaki" sort="Nakahara, Tadaki" uniqKey="Nakahara T" first="Tadaki" last="Nakahara">Tadaki Nakahara</name><name sortKey="Sakata, Michio" sort="Sakata, Michio" uniqKey="Sakata M" first="Michio" last="Sakata">Michio Sakata</name><name sortKey="Shimada, Toshiyuki" sort="Shimada, Toshiyuki" uniqKey="Shimada T" first="Toshiyuki" last="Shimada">Toshiyuki Shimada</name><name sortKey="Suzuki, Takayuki" sort="Suzuki, Takayuki" uniqKey="Suzuki T" first="Takayuki" last="Suzuki">Takayuki Suzuki</name><name sortKey="Wada, Masahiro" sort="Wada, Masahiro" uniqKey="Wada M" first="Masahiro" last="Wada">Masahiro Wada</name></noCountry><country name="Japon"><region name="Région de Kantō"><name sortKey="Mukai, Makio" sort="Mukai, Makio" uniqKey="Mukai M" first="Makio" last="Mukai">Makio Mukai</name></region><name sortKey="Ikeda, Tadashi" sort="Ikeda, Tadashi" uniqKey="Ikeda T" first="Tadashi" last="Ikeda">Tadashi Ikeda</name><name sortKey="Kitajima, Masaki" sort="Kitajima, Masaki" uniqKey="Kitajima M" first="Masaki" last="Kitajima">Masaki Kitajima</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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